UChicago Medicine Fredric L. Coe Symposium on Kidney Stone Disease and Mineral Metabolism

1. Overview

The UChicago Medicine Fredric L. Coe Symposium on Kidney Stone Disease and Mineral Metabolism offers a comprehensive and clinically focused exploration of kidney stone disease, with an emphasis on pathophysiology, prevention, and patient management.

This program provides an in-depth review of mineral metabolism and its relationship to nephrolithiasis, including key topics such as idiopathic hypercalciuria, kidney stone composition, and the role of systemic acid-base balance in stone formation.

Designed to bridge current knowledge gaps, the symposium highlights recent advancements in renal physiology and the mechanisms underlying kidney stone development. It supports evidence-based clinical decision-making through the integration of research findings and practical treatment strategies.

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2. Learning Objectives

Participants will be able to:

• Evaluate the relationship between bone health, mineral metabolism, and kidney stone formation

• Utilize kidney stone compositional analysis to guide targeted prevention and treatment strategies

• Analyze the connection between idiopathic hypercalciuria and papillary mineral deposition

• Assess the role of systemic acid-base balance and urinary pH in influencing stone risk

• Apply evidence-based approaches for the diagnosis, management, and prevention of brushite stones

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3. Target Audience

This program is intended for:

• Nephrologists seeking advanced insights into kidney stone disease

• Urologists focused on diagnosis and management of nephrolithiasis

• Healthcare professionals interested in mineral metabolism and renal disorders

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4. Key Learning Areas

Kidney Stone Pathophysiology

• Mechanisms of stone formation

• Relationship between renal physiology and mineral balance

Mineral Metabolism and Bone Health

• Interplay between calcium metabolism and skeletal health

• Clinical implications for stone development

Compositional Analysis and Diagnostics

• Importance of stone analysis in treatment planning

• Laboratory and clinical evaluation strategies

Metabolic and Systemic Factors

• Idiopathic hypercalciuria and its clinical significance

• Role of acid-base balance and urinary chemistry

Clinical Management and Prevention

• Evidence-based strategies for reducing recurrence

• Targeted management of specific stone types, including brushite stones

Clinical Research and Innovation

• Integration of clinical practice with research insights

• Evolving approaches in kidney stone clinics

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5. Program Topics

1. Symposium Welcome

2. Opening and Introductory Remarks

3. Foundations of Bone and Stone Interactions

4. Advances in Kidney Stone Compositional Analysis

5. Idiopathic Hypercalciuria and Papillary Mineral Deposits

6. Acid-Base Balance and Kidney Stone Risk

7. Clinical Insights into Brushite Stones

8. The Role of Specialized Stone Clinics in Patient Care and Research

9. Concluding Remarks

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This symposium provides a structured and evidence-based educational experience for clinicians aiming to deepen their understanding of kidney stone disease and improve patient outcomes through advanced diagnostic and management strategies.