Product Overview

For more than five decades, Sleisenger & Fordtran’s Gastrointestinal and Liver Disease has served as a leading reference for gastroenterology and hepatology professionals, trainees, students, and the broader multidisciplinary gastrointestinal care team.

The 12th Edition continues this tradition with a comprehensive two-volume resource covering gastrointestinal and liver disease from foundational science and pathophysiology through contemporary diagnostic techniques, treatment strategies, and clinical management.

The edition brings together contributions from experts across the field and provides an extensive overview of modern gastroenterology and hepatology. Its consistent structure, more than 1,100 full-color illustrations, practical clinical algorithms, and accompanying procedural videos are designed to make complex information accessible for both clinical reference and advanced learning.

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Key Features

Comprehensive Gastroenterology and Hepatology Coverage

Provides detailed coverage across the gastrointestinal tract, pancreas, biliary system, and liver, integrating basic science with clinical diagnosis and treatment.

Updated Clinical Content

The 12th Edition includes expanded and updated discussions of important developments in contemporary gastrointestinal and liver medicine, including:

• Eosinophilic gastrointestinal disorders
• Metabolic dysfunction-associated steatotic liver disease (MASLD)
• Artificial intelligence applications in endoscopy
• New approaches to the detection of gastrointestinal cancers
• Advances in treatment for viral hepatitis
• New therapies for autoimmune liver diseases
• Expanded treatment options for inflammatory bowel disease
• Gastrointestinal and hepatic manifestations of coronavirus infection
• Enterocolitis and hepatitis associated with cancer immunotherapy
• Neoplasia involving multiple organs

Practical Clinical Algorithms

Quick-reference algorithms summarize clinical decision-making and provide practical approaches to patient assessment and management.

Endoscopic Procedures

The text provides coverage of a broad range of endoscopic procedures used for diagnosis and treatment, including:

• Balloon dilation
• Stent placement and removal
• Management of small-bowel angioectasia
• Other contemporary diagnostic and therapeutic endoscopic techniques

Visual Learning Resources

More than 1,100 full-color illustrations support understanding of anatomy, pathology, diagnostic findings, and clinical concepts.

Endoscopic Procedure Videos

The digital content includes more than 20 videos demonstrating endoscopic procedures and techniques.

Consistent Organization

A standardized, templated format throughout the text makes it easier to locate information quickly and compare clinical concepts across different disease categories.

Included eBook

An eBook version is included with purchase, providing digital access to the text, figures, and references.

The eBook allows users to:

• Search the complete content
• Customize their reading experience
• Add notes and highlights
• Access figures and references
• Use read-aloud functionality

Additional digital ancillary content may become available following publication.

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Who Is This Reference For?

This comprehensive resource is designed for:

• Gastroenterologists
• Hepatologists
• Gastroenterology and hepatology fellows
• Internal medicine physicians
• Medical residents
• Medical students
• Gastrointestinal surgeons
• Advanced practice providers
• Multidisciplinary gastrointestinal care teams
• Healthcare professionals involved in digestive and liver disease management

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Table of Contents

Part I — Biology of the Gastrointestinal Tract

1. Cellular Growth and Neoplasia

2. Mucosal Immunology and Inflammation

3. The Enteric Microbiota

4. Gut Sensory Transduction

5. Biopsychosocial Issues in Gastroenterology

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Part II — Nutrition in Gastroenterology

6. Nutritional Principles and Assessment of the Gastroenterology Patient

7. Nutritional Management

8. Obesity

9. Surgical and Endoscopic Treatment of Obesity

10. Feeding and Eating Disorders

11. Food Allergies

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Part III — Symptoms and Signs

12. Acute Abdominal Pain

13. Chronic Abdominal Pain

14. Symptoms of Esophageal Disease

15. Dyspepsia

16. Nausea and Vomiting

17. Diarrhea

18. Intestinal Gas

19. Fecal Incontinence

20. Constipation

21. Gastrointestinal Bleeding

22. Jaundice

23. Factitious Gastrointestinal Diseases

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Part IV — Processes Involving Multiple Organs

24. Oral Diseases and Oral Manifestations of Gastrointestinal and Liver Diseases

25. Cutaneous Manifestations of Gastrointestinal and Liver Diseases

26. Diverticula of the Pharynx, Esophagus, Stomach, and Small Intestine

27. Abdominal Hernias and Gastric Volvulus

28. Foreign Bodies, Bezoars, and Caustic Ingestions

29. Abdominal Abscesses and Gastrointestinal Fistulas

30. Eosinophilic Disorders of the Gastrointestinal Tract

31. Protein-Losing Gastroenteropathy

32. Gastrointestinal and Hepatic Manifestations of Coronavirus Infection

33. Gastrointestinal Consequences of Infection With Human Immunodeficiency Virus

34. Gastrointestinal and Hepatic Complications of Solid Organ and Hematopoietic Cell Transplantation

35. Gastrointestinal and Hepatic Manifestations of Systemic Diseases

36. Vascular Lesions of the Gastrointestinal Tract

37. Surgical Peritonitis and Other Diseases of the Peritoneum, Mesentery, Omentum, and Diaphragm

38. Gastrointestinal and Hepatic Disorders in the Pregnant Patient

39. Acute and Chronic Gastrointestinal Side Effects of Radiation Therapy

40. Preparation for and Complications of GI Endoscopy

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Part V — Neoplasia Involving Multiple Organs

41. Gastrointestinal Lymphomas

42. Gastrointestinal Stromal Tumors

43. Neuroendocrine Tumors

44. Enterocolitis and Hepatitis Induced by Cancer Immunotherapy

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Part VI — Esophagus

45. Anatomy, Histology, Embryology, and Developmental Anomalies of the Esophagus

46. Esophageal Neuromuscular Function and Motility Disorders

47. Esophageal Disorders Caused by Medications, Trauma, and Infection

48. Gastroesophageal Reflux Disease

49. Barrett Esophagus

50. Esophageal Tumors

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Part VII — Stomach and Duodenum

51. Anatomy, Histology, and Developmental Anomalies of the Stomach and Duodenum

52. Gastric Neuromuscular Function and Neuromuscular Disorders

53. Gastric Secretion

54. Gastritis and Gastropathy

55. Peptic Ulcer Disease

56. Adenocarcinoma of the Stomach and Other Gastric Tumors

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Part VIII — Pancreas

57. Anatomy, Histology, Embryology, and Developmental Anomalies of the Pancreas

58. Exocrine Pancreatic Secretion

59. Genetic Disorders of the Pancreas and Pancreatic Disorders in Childhood

60. Acute Pancreatitis

61. Chronic Pancreatitis

62. Pancreatic Cancer, Cystic Neoplasms, and Other Tumors

63. Endoscopic Treatment of Pancreatic Disease

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Part IX — Biliary Tract

64. Anatomy, Histology, Embryology, Developmental Anomalies, and Pediatric Disorders of the Biliary Tract

65. Biliary Tract Motor Function and Dysfunction

66. Bile Formation and Bile Acid Cycling in Health and Disease

67. Gallstone Disease

68. Treatment of Gallstone Disease

69. Acalculous Biliary Pain, Acute Acalculous Cholecystitis, Cholesterolosis, Adenomyomatosis, and Gallbladder Polyps

70. Primary and Secondary Sclerosing Cholangitis

71. Tumors of the Bile Ducts, Gallbladder, and Ampulla

72. Endoscopic and Radiologic Treatment of Biliary Disease

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Part X — Liver

73. Embryology, Anatomy, Histology, and Developmental Anomalies of the Liver

74. Liver Physiology and Energy Metabolism

75. Liver Chemistry and Function Tests

76. Overview of Cirrhosis

77. Hemochromatosis

78. Wilson Disease

79. Other Inherited Metabolic Disorders of the Liver

80. Hepatitis A

81. Hepatitis B

82. Hepatitis C

83. Hepatitis D

84. Hepatitis E

85. Hepatitis Caused by Other Viruses

86. Bacterial, Parasitic, and Fungal Infections of the Liver, Including Liver Abscesses

87. Vascular Diseases of the Liver

88. Alcohol-Associated Liver Disease

89. Metabolic Dysfunction-Associated Steatotic Liver Disease / Nonalcoholic Fatty Liver Disease

90. Liver Disease Caused by Drugs

91. Liver Disease Caused by Anesthetics, Chemicals, Toxins, and Herbal and Dietary Supplements

92. Autoimmune Hepatitis

93. Primary Biliary Cholangitis

94. Portal Hypertension and Variceal Bleeding

95. Ascites and Spontaneous Bacterial Peritonitis

96. Hepatic Encephalopathy, Hepatorenal Syndrome, Hepatopulmonary Syndrome, and Other Systemic Complications of Liver Disease

97. Acute Liver Failure

98. Hepatic Tumors and Cysts

99. Liver Transplantation

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Part XI — Small and Large Intestine

100. Anatomy, Histology, Embryology, and Developmental Anomalies of the Small and Large Intestine

101. Small Intestinal Motor and Sensory Function and Dysfunction

102. Colonic Motor and Sensory Function and Dysfunction

103. Intestinal Electrolyte Absorption and Secretion

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Part XII — Additional Treatments for Patients with Gastrointestinal and Liver Disease

104. Complementary, Alternative, and Integrative Medicine

105. Palliative Care Medicine in Patients With Advanced Gastrointestinal and Hepatic Disease

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Comprehensive Clinical Coverage

The 12th Edition provides extensive coverage of the full spectrum of gastrointestinal and hepatobiliary medicine, including:

• Gastrointestinal anatomy and physiology
• Mucosal immunology and inflammation
• Nutrition and obesity
• Gastrointestinal symptoms and diagnostic evaluation
• Esophageal disease
• Gastric and duodenal disorders
• Pancreatic disease
• Biliary disorders
• Liver disease and cirrhosis
• Viral and autoimmune hepatitis
• Inflammatory and eosinophilic disorders
• Gastrointestinal and hepatobiliary cancers
• Neuroendocrine tumors
• Gastrointestinal stromal tumors
• Gastrointestinal bleeding
• Endoscopic diagnosis and treatment
• Gastrointestinal infections
• Transplant-related complications
• Gastrointestinal manifestations of systemic disease
• Pregnancy-related gastrointestinal and liver disorders
• Complementary and integrative medicine
• Palliative care for advanced gastrointestinal and hepatic disease

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Product Summary

Sleisenger & Fordtran’s Gastrointestinal and Liver Disease, 12th Edition — 2-Volume Set is an extensive reference for contemporary gastroenterology and hepatology. Combining foundational science, clinical diagnosis, therapeutic approaches, procedural guidance, visual resources, clinical algorithms, and digital learning materials, the set is designed to support both advanced education and day-to-day clinical reference.