Overview :

Personalised Medicine in Reproduction is a multidisciplinary educational programme focused on applying precision medicine principles across the reproductive care pathway.

The programme connects molecular and genetic insights, clinical data, digital tools, laboratory science, and patient-centred care to explore more individualised approaches to diagnosis, ovarian stimulation, gamete care, embryo selection, implantation, pregnancy management, and reproductive decision-making.

Through case-based education, methodology-focused sessions, and interactive discussions, participants examine how personalised approaches can move fertility care beyond standardised protocols toward individualised, evidence-informed, outcomes-focused treatment pathways.

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Programme Overview

The programme follows the reproductive care pathway from preconception assessment through pregnancy, with a focus on integrating clinical, laboratory, genetic, lifestyle, and data-driven information.

Core Areas

• Personalised reproductive diagnostics
• Genomic and genetic risk assessment
• Hormonal and metabolic profiling
• Lifestyle optimisation
• Individualised ovarian stimulation
• Luteal phase support
• Gamete and male-factor assessment
• Precision embryo assessment
• Embryo selection and transfer timing
• Endometrial receptivity
• Implantation failure
• Recurrent pregnancy loss
• Data science and artificial intelligence
• Reproductive ethics and patient communication
• Individualised pregnancy surveillance

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What You Will Learn

1. Personalised Diagnostic Workups

Learn how to develop individualised diagnostic pathways by integrating multiple sources of patient information.

Key considerations include:

• Genomic and genetic information
• Hormonal profiles
• Metabolic and thyroid assessment
• Imaging
• Lifestyle factors
• Previous reproductive history
• Individual treatment response
• Relevant microbiome considerations

The programme explores how these data can be integrated into a structured diagnostic approach rather than relying on a single test or standardised assessment pathway.

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2. Ovarian Stimulation Personalisation

Individual differences in ovarian biology and previous treatment response can influence the selection of stimulation strategies.

Educational topics include:

• Individualised ovarian stimulation
• Dose selection and adjustment
• Ovarian response assessment
• Stimulation algorithms
• LH and HCG trigger strategies
• Previous cycle response
• Ovarian biology
• OHSS risk assessment and management
• Individualised luteal support

The programme focuses on developing treatment strategies that account for individual patient characteristics while maintaining safety and clinical effectiveness.

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3. Gamete Care and Male-Factor Personalisation

The programme addresses personalised approaches to male-factor infertility and gamete assessment.

Topics include:

• Advanced semen testing
• Sperm DNA fragmentation
• Genetic assessment
• Male reproductive factors
• Sperm selection techniques
• Varicocele considerations
• Medical treatment options
• Individualised gamete selection strategies

The aim is to integrate male-factor information into broader reproductive treatment planning rather than treating male infertility as an isolated component of the IVF pathway.

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4. Precision Embryo Assessment

Embryo assessment and selection are important components of personalised IVF.

The programme examines:

• Embryo morphology
• Embryo development
• Morphokinetics
• Embryo selection criteria
• Embryo transfer timing
• Single-embryo strategies
• Adjunctive testing
• Appropriate and inappropriate use of additional tests

Participants explore how laboratory information can support embryo selection while critically evaluating the evidence behind emerging assessment tools and adjunctive approaches.

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5. Endometrial Receptivity and Personalised Endometrial Care

The programme examines approaches to assessing and managing the endometrium in patients undergoing assisted reproductive treatment.

Key areas include:

• Endometrial receptivity assessment
• Endometrial preparation
• Inflammation and infection evaluation
• Luteal phase support
• Individualised treatment strategies
• Embryo-endometrial interaction
• Clinical interpretation of endometrial findings

The emphasis is on using appropriate evidence to determine when additional assessment or intervention may be clinically justified.

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6. Implantation Failure and Recurrent Pregnancy Loss

The programme provides a structured approach to complex reproductive outcomes, including implantation failure and recurrent pregnancy loss (RPL).

Topics include:

• Stepwise evaluation of implantation failure
• Recurrent pregnancy loss
• Thrombophilia considerations
• Autoimmune factors
• Clinical investigation
• Evidence-based interventions
• Individualised management
• Avoidance of unnecessary testing and treatment

The programme encourages a pragmatic approach that balances thorough investigation with appropriate use of evidence and clinical judgement.

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7. Data Science and Artificial Intelligence in Reproductive Medicine

Data and artificial intelligence are increasingly being explored as tools for supporting personalised reproductive care.

The programme examines:

• Predictive models
• Clinical decision-support tools
• Data dashboards
• Model validation
• Bias control
• Overfitting
• Clinical data integration
• Registries
• Real-world evidence
• Responsible use of AI

Participants learn how data-driven tools can support clinical decision-making while recognising the importance of validation, transparency, bias assessment, and appropriate interpretation.

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8. Ethics, Equity and Patient Communication

Personalised medicine requires more than advanced technology. Patients need clear information to make informed decisions about testing and treatment.

This section addresses:

• Informed consent
• Patient autonomy
• Shared decision-making
• Equity and access
• Cost-effectiveness
• Communication of uncertainty
• Benefits and limitations of interventions
• Evaluation of IVF add-ons
• Transparent treatment counselling
• Patient-centred care

The programme promotes clear and balanced communication so that patients can understand the potential benefits, limitations, costs, and uncertainties associated with personalised treatment options.

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9. Individualised Pregnancy Management After ART

Personalised reproductive care continues beyond embryo transfer and implantation.

The programme explores individualised surveillance during pregnancy following assisted reproductive treatment, including consideration of:

• Hypertensive disorders
• Gestational diabetes
• Multiple pregnancy
• Individual risk factors
• Pregnancy monitoring
• Post-ART maternal care
• Patient-specific surveillance strategies

The focus is on extending personalised care throughout the reproductive journey rather than ending the approach at successful implantation.

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Programme Structure

The educational programme follows a structured progression through the reproductive care pathway:

Diagnostics

• Preconception profiling
• Genetic risk
• Metabolic and thyroid assessment
• Lifestyle factors
• Relevant microbiome considerations

Stimulation and Gamete Care

• Individualised ovarian stimulation
• Dose algorithms
• Trigger strategies
• OHSS risk management
• Male-factor assessment
• Advanced semen testing
• Genetic evaluation

Embryo and Endometrium

• Embryo assessment
• Morphokinetics
• Embryo selection
• Transfer timing
• Endometrial receptivity
• Inflammation and infection assessment
• Luteal support

Implantation and Pregnancy

• Implantation failure
• Recurrent pregnancy loss
• Stepwise evaluation
• Individualised interventions
• Pregnancy surveillance following ART

Data and Ethics

• Artificial intelligence
• Predictive modelling
• Model validation
• Bias management
• Real-world evidence
• Informed consent
• Equity and access
• Patient autonomy

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Educational Format

The programme uses a combination of:

• Case-based lectures
• Methodology workshops
• Interactive panels
• Clinical examples
• Evidence-based discussions
• Practical decision-making approaches

The content is structured to help participants connect scientific concepts with real-world clinical applications.

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Practical Takeaways

The programme is designed to provide resources that can be applied directly to clinical practice, including:

• Clinical checklists
• Decision aids
• Structured assessment approaches
• Treatment planning frameworks
• Documentation strategies
• Patient counselling approaches
• Sample counselling scripts
• Evidence-based decision-making tools

These resources are intended to support more consistent, transparent, and patient-centred approaches to personalised reproductive care.

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Key Topics

Preconception Profiling

• Genetic risk assessment
• Metabolic and thyroid factors
• Microbiome considerations
• Lifestyle optimisation

Ovarian Stimulation

• Personalised dosing
• Dose algorithms
• LH and HCG trigger strategies
• Ovarian response
• OHSS risk management

Embryo Selection and Transfer

• Embryo morphology
• Morphokinetics
• Embryo selection
• Transfer timing
• Single-embryo strategies
• Adjunctive testing

Endometrium

• Receptivity assessment
• Endometrial preparation
• Inflammation and infection evaluation
• Tailored luteal support

Implantation Failure and Recurrent Pregnancy Loss

• Stepwise evaluation
• Thrombophilia considerations
• Autoimmune considerations
• Pragmatic treatment strategies

Male Factor

• Advanced semen analysis
• DNA fragmentation
• Genetic testing
• Sperm selection
• Varicocele management
• Medical treatment options

Data Science and AI

• Predictive modelling
• Model validation
• Bias control
• Clinical registries
• Real-world evidence
• Decision-support tools

Ethics, Equity and Access

• Informed consent
• Patient autonomy
• Shared decision-making
• Add-on evaluation
• Cost-effectiveness
• Equitable access to personalised care

Pregnancy After ART

• Individualised pregnancy surveillance
• Hypertensive disorders
• Gestational diabetes
• Multiple pregnancy risk
• Patient-specific monitoring

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Who Should Attend?

The programme is designed for professionals across reproductive medicine and related disciplines, including:

• Reproductive endocrinologists
• Infertility specialists
• Embryologists
• Andrology teams
• Genetics professionals
• Maternal-fetal medicine clinicians
• Nurses and midwives
• Fertility counsellors
• Data scientists
• Biostatisticians working in assisted reproductive technology
• Trainees in reproductive medicine and related fields

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Why Attend?

Personalised Medicine in Reproduction provides a practical framework for transforming standardised fertility protocols into more individualised and outcomes-focused care pathways.

Participants can develop approaches for:

• Integrating laboratory and clinical data
• Improving treatment individualisation
• Supporting safety and efficiency
• Optimising patient selection
• Standardising documentation
• Strengthening patient counselling
• Evaluating emerging technologies
• Supporting transparent treatment decisions
• Addressing uncertainty and evidence limitations

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Conference Video Content

The programme includes continuous video recordings of the conference sessions, providing access to the educational content presented throughout the event.

The recordings include the individual sessions covering the programme's clinical, laboratory, technological, ethical, and patient-centred topics.

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Comprehensive Personalised Reproductive Medicine Education

ESHRE Personalised Medicine in Reproduction provides an integrated approach to precision reproductive care, connecting genomics, reproductive biology, clinical assessment, laboratory science, artificial intelligence, data analysis, and patient-centred decision-making.

From preconception profiling and ovarian stimulation to embryo selection, endometrial assessment, implantation, recurrent pregnancy loss, and pregnancy following assisted reproduction, the programme examines how treatment can be adapted to individual patient characteristics.

The course also emphasises responsible implementation, recognising that personalised medicine must be supported by clinical evidence, appropriate validation, ethical practice, transparent communication, and equitable access.

It is a comprehensive educational resource for professionals seeking to understand and implement the evolving principles of precision medicine and individualised care in reproductive healthcare.