Mayo Clinic’s 9th Annual Hematology/Oncology Case-Based Approaches to Patient Care for Advanced Practice Providers and Nurses – 2026 is a comprehensive educational program focused on the evolving needs of healthcare professionals caring for patients with hematologic and oncologic malignancies.

Presented in a practical, case-based format, the program explores real-world clinical challenges in hematology and oncology. It provides educational insights into diagnosis, treatment selection, supportive care, complications, emerging therapies, and multidisciplinary patient management.

The collection includes a convenient resource for review and continued professional education.

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Target Audience

This program is particularly relevant for:

• Physicians
• Physician Assistants
• Nurse Practitioners
• Advanced Practice Providers
• Oncology Nurses
• Hematology Nurses
• Residents and Fellows
• Pharmacists
• Healthcare professionals involved in hematology, oncology, and internal medicine

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Learning Objectives

Upon completion of the program, participants should be able to:

• Differentiate between immunotherapy, targeted therapy, chemotherapy, and radiation therapy.
• Select appropriate treatment approaches according to cancer type and disease stage.
• Apply current evidence-based strategies to the diagnosis and treatment of common hematologic and oncologic malignancies.
• Evaluate indications and patient eligibility for bone marrow transplantation and CAR T-cell therapy.
• Incorporate palliative and supportive care principles into comprehensive cancer treatment plans.
• Improve symptom management and quality of life for patients receiving cancer treatment.
• Recognize common complications and adverse effects associated with immunotherapy, targeted therapy, chemotherapy, and radiation therapy.
• Apply current clinical guidelines and appropriate clinical judgment when managing treatment-related complications.
• Strengthen interdisciplinary communication, coordination, and collaborative patient care through case-based learning.

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Program Breakdown

Day 1 — Hematology & Oncology Case-Based Approaches

Opening & Introduction

• Program welcome and introduction
• Overview of the educational objectives and case-based format

The Role of Advanced Practice Providers in Cancer Care

• Financial, social, and emotional considerations in cancer care
• The impact of advanced practice providers on patient outcomes and cancer care delivery

Complex Cancer Case Studies

• Case-based discussion of cholangiocarcinoma
• Evolving treatment considerations and clinical decision-making
• Liver transplantation as a potential option in selected metastatic colorectal cancer cases

Unusual Plasma Cell Malignancies

• Recognition and evaluation of uncommon plasma cell disorders
• Practical considerations in diagnosis and management

Cancer-Associated Thrombosis

• Identification of thrombosis associated with malignancy
• Clinical assessment and management considerations

T-Cell Engaging Therapies

• Long-term considerations associated with T-cell engaging therapies
• Clinical insights through case-based discussions

Interactive Q&A Discussions

• Case-based questions
• Clinical discussion and knowledge reinforcement

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Day 2 — Hematologic Malignancies, Immunotherapy & Supportive Care

Chronic Graft-Versus-Host Disease

• Practical approaches to chronic GVHD
• Case-based management considerations for advanced practice providers and nurses

Suspected Acute Leukemia

• Recognizing clinical and laboratory findings that may suggest acute leukemia
• Initial evaluation and appropriate clinical approach

Modern Multiple Myeloma Treatment

• Emerging approaches to multiple myeloma
• Case-based perspectives on bispecific antibodies
• Treatment considerations and patient management

Novel Therapeutics in Melanoma

• Contemporary treatment strategies
• Novel therapeutic approaches in melanoma care

Immunotherapy Toxicities

• Recognition of immune-related adverse events
• Assessment and management considerations

Neuroendocrine Tumors

• Case-based approach to the diagnosis and management of neuroendocrine malignancies
• Considerations for complex and less common presentations

Cancer Pain Management

• Assessment and management of cancer-related pain
• Supportive care strategies for improving patient comfort and quality of life

Care After Bone Marrow Transplantation

• Continuity of care following transplantation
• Safe transitions between healthcare settings
• Care coordination and communication

Infusion Center Reactions

• Recognition and management of unexpected reactions
• Practical considerations for safe infusion-center care

Interactive Q&A Discussions

• Case-based questions and clinical discussions
• Review of key concepts from the day's sessions

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Day 3 — Cancer Complications, Cellular Therapy & Clinical Practice

Communicating About Low-Evidence Treatments

• Approaches to discussing controversial or low-evidence treatments with patients
• Supporting informed, evidence-based healthcare decisions
• Effective patient communication

Cardiovascular Complications of Cancer Therapy

• Recognition of cardiovascular complications associated with cancer treatment
• Clinical case-based approaches to assessment and management

Cellular Therapies for Autoimmune Disease

• Overview of cellular therapy applications
• Clinical considerations and emerging therapeutic approaches

Oral Chemotherapy

• Key considerations in oral anticancer therapy
• Patient education, treatment monitoring, and medication management

Gastrointestinal Malignancies

• Approach to GI malignancies in hospitalized patients
• Clinical assessment and management considerations

Long-Term Hematology/Oncology Practice

• Professional challenges and opportunities in a long-term hematology/oncology career
• Practical lessons for advanced practice providers
• Maintaining effective patient-centered care throughout a clinical career

Final Review

• Interactive case-based discussion
• Knowledge assessment
• Program closing and final review

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Key Topics Covered

The program provides broad coverage of important hematology and oncology topics, including:

• Hematologic malignancies
• Solid tumors
• Cholangiocarcinoma
• Metastatic colorectal cancer
• Plasma cell malignancies
• Cancer-associated thrombosis
• Multiple myeloma
• Bispecific antibodies
• Melanoma
• Neuroendocrine tumors
• Acute leukemia
• Chronic graft-versus-host disease
• Bone marrow transplantation
• CAR T-cell therapy
• Cellular therapies
• Immunotherapy
• Targeted therapy
• Chemotherapy
• Oral chemotherapy
• Radiation therapy
• Immunotherapy-related toxicities
• Cardiovascular complications of cancer treatment
• Cancer pain management
• Infusion-related reactions
• Supportive and palliative care
• Patient communication
• Multidisciplinary cancer care

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The product includes:

• Recorded educational video sessions
• Accompanying PDF presentation materials
• Case-based educational content
• Clinical discussions and Q&A sessions
• Comprehensive hematology and oncology topics
• Materials suitable for review and self-directed learning

Product Format

Video: Live-recorded course sessions
Documents: PDF educational materials
Content: Case-based hematology and oncology education
Edition: 9th Annual — 2026

Summary

Mayo Clinic’s 9th Annual Hematology/Oncology Case-Based Approaches to Patient Care – 2026 provides a practical, case-focused educational resource for clinicians involved in hematology and oncology. The program combines clinical cases, treatment approaches, emerging therapies, supportive care, and management of treatment-related complications.